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Today's Rundown Apellis climbs as its drug beats Alexion's Soliris in phase 3 As Rhythm Pharmaceuticals preps for first approval, CEO hits the exit AstraZeneca taps MiNA to treat metabolic diseases by activating genes Magenta CSO Michael Cooke jumps to IFM Therapeutics Galecto to merge with onetime Celgene partner PharmAkea Arcutis eyes $100M IPO to bankroll dermatology programs Deep Genomics nabs $40M round, doubles down on AI and Wilson disease work A new strategy for boosting PD-1 blockers in melanoma Merck's Keytruda misses key mark in small cell lung cancer trial, dashing big expansion hopes Featured Story | | | Tuesday, January 7, 2020 Apellis Pharmaceuticals’ pegcetacoplan has beaten Alexion’s blockbuster Soliris in a head-to-head phase 3 trial. The result suggests Apellis can challenge Alexion’s dominance in paroxysmal nocturnal hemoglobinuria, but the biotech needs to talk to the FDA before deciding on the next steps. |
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Top Stories Tuesday, January 7, 2020 Fierce 15 winner Rhythm Pharmaceuticals is on the cusp of gaining its first approval in 2020, but it will be ushering in this potential milestone without its chief. Tuesday, January 7, 2020 AstraZeneca has teamed up with MiNA Therapeutics to test small activating RNA (saRNA) molecules in metabolic diseases. The agreement gives AstraZeneca the option to negotiate a license for saRNA molecules after getting a look at preclinical data on the candidates. Tuesday, January 7, 2020 IFM Therapeutics snagged a new chief scientific officer. Michael Cooke, Ph.D., joins from stem cell biotech Magenta Therapeutics, where he held the same position. He arrives a month after IFM promoted R&D chief Martin Seidel, Ph.D. to CEO and raised $55.5 million to bankroll an incubator and up to three new subsidiaries. Tuesday, January 7, 2020 Galecto is set to merge with PharmAkea. The deal will see Denmark’s Galecto incorporate in the U.S. and add a clinical-phase treatment for idiopathic pulmonary fibrosis (IPF) to its pipeline. Tuesday, January 7, 2020 Dermatology player Arcutis Biotherapeutics set up shop in 2016 but stayed under the radar until early last year. Now, with a trio of clinical-stage programs and more than $160 million in the bank, the company is looking to hit the street with a $100 million IPO. Tuesday, January 7, 2020 Canadian drug development company Deep Genomics has got off a $40 million series B round as it looks to double down on its rare genetic disease and artificial intelligence work. Tuesday, January 7, 2020 In melanoma, at least half of patients don’t respond to PD-1 blockers like Bristol-Myers Squibb’s Opdivo and Merck’s Keytruda. Sanford Burnham researchers are proposing a new way to sensitize melanoma to PD-1 blockade by inhibiting a protein called Siah2. In mouse models, the strategy restricted T regulatory cells, allowing killer T cells to attack the cancer. Tuesday, January 7, 2020 Merck & Co.’s Keytruda may be the star in non-small cell lung cancer, but a combo of it and chemo just failed to significantly outdo chemo alone at prolonging patients’ lives in small cell lung cancer, a market that one analyst dubbed "one of the largest metastatic market opportunities remaining" for the PD-1 drug. | | Experts in our field; with 20+ years’ experience in Viral Vector & plasmid DNA (R&D, High Quality and GMP) manufacture for pre-clinical, clinical & commercial supply. Take a virtual tour of our facilities & find out more about our expansion project. |
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