Takeda chops 4 cancer candidates

Today’s Big News

Feb 2, 2024

In obesity, Regeneron wants to fill gaps. But for cell therapy? Yancopoulos wants to try something new


BMS more likely to bet on bolt-ons after recent buying spree


Takeda drops cancer candidates, axing immunocytokine and CAR-Ts amid shifting treatment landscape


Alto, Fractyl head to public markets with IPOs north of $100M each


AstraZeneca's phase 3 heart disease trial hits, teeing up Pfizer showdown in Japan


Amid CEO turmoil, Allarity loses rights to Novartis cancer drug over missed payments


Chutes & Ladders—Ex-Eisai leader Ivan Cheung tapped to be new CEO of NextPoint


Fierce Biotech Layoff Tracker 2024: 2nd layoff wave at Atara Bio; Cuts at Xencor

The Top Line Podcast: Don’t miss out on the newest episode. Listen now.

 

Featured

In obesity, Regeneron wants to fill gaps. But for cell therapy? Yancopoulos wants to try something new

Regeneron wants to improve on obesity care with a muscle-preservation approach, while elsewhere, the biopharma charts a new course in cell therapy thanks to the acquisition of 2seventy's pipeline.
 

Top Stories

BMS more likely to bet on bolt-ons after recent buying spree

Bristol Myers Squibb is focused on integrating its new acquisitions, but CEO Chris Boerner said there's still interest in more development, which likely would center on bolt-on deals.

Takeda drops cancer candidates, axing immunocytokine and CAR-Ts amid shifting treatment landscape

Takeda’s vision of becoming a leader in oncology ran into more trouble Thursday, when the drugmaker axed a midphase immunocytokine and three early-stage CAR-T cell therapy prospects from its R&D pipeline.

Alto, Fractyl head to public markets with IPOs north of $100M each

In a second busy week of biotech IPOs, Alto Neuroscience and Fractyl Health will both be jumping onto the public markets this morning with their sights set on raking in over $100 million each.

AstraZeneca's phase 3 heart disease trial hits, teeing up Pfizer showdown in Japan

AstraZeneca has the data to mount an attack on Pfizer’s dominance of a heart disease market. Friday, the Anglo-Swedish drugmaker reported positive top-line results from a phase 3 trial of acoramidis in Japan, teeing it up to file for regulatory approval in the country.

Amid CEO turmoil, Allarity loses rights to Novartis cancer drug over missed payments

Already reeling from the controversial termination of its CEO, Allarity Therapeutics has now been told that Novartis is rescinding the rights to a troubled cancer drug after the biotech failed to keep up with its payments.

Chutes & Ladders—Ex-Eisai leader Ivan Cheung tapped to be new CEO of NextPoint

After helping lead approval of Eisai, Biogen-partnered Alzheimer's med, Ivan Cheung will take the reins of NextPoint Therapeutics. 2seventy's reshuffle sends CSO to Regeneron as cell therapy unit leader. Sanofi swaps CFOs, naming ex-Nestle, Takeda financial chief.

Fierce Biotech Layoff Tracker 2024: 2nd layoff wave at Atara Bio; Cuts at Xencor

We really didn't want to have to create another Layoff Tracker this year. But here we are, launching the third annual iteration tracking biopharma layoffs. 

'The Top Line': Navigating the future of medical AI

This week on “The Top Line,” Fierce’s Conor Hale interviews Peter Shen, the North American head of digital health at Siemens Healthineers, to explore what developers and regulators can do to ensure transparency in medical AI. He also dives into how the field could potentially benefit from a 21st-century update to the Hippocratic Oath. 

As Humira plummets, AbbVie dials up Rinvoq and Skyrizi estimates to a combined $27B

Sales of Humira—which once sat pretty as the world’s best-selling drug—plunged nearly 41% to $3.3 billion in the third quarter.

Hospital-backed proposal would make insurers reveal prior auth denial rates

The Federation of American Hospitals is pushing CMS for the inclusion of a star ratings quality measure that shows how often insurers overturn or uphold prior authorization denials.

Fierce Pharma Asia—Takeda's $300M deal; Lonza's plant closure; US bill targets certain Chinese firms

Takeda paid $300 million upfront to license a blood disorder candidate. Lonza will close a biologics plant in China. A U.S. draft bill targets several Chinese biotech companies. And more.
 
Fierce podcasts

Don’t miss an episode

'The Top Line': Navigating the future of medical AI

This week on “The Top Line,” Fierce’s Conor Hale interviews Peter Shen, the North American head of digital health at Siemens Healthineers, to explore what developers and regulators can do to ensure transparency in medical AI. He also dives into how the field could potentially benefit from a 21st-century update to the Hippocratic Oath. 
 

Resources

Whitepaper

The Oncology Market – 2023 Year in Review

This paper offers a detailed review of key events and developments in the oncology market during 2023.  It’s a helpful “status report” that informs how the market is likely to evolve in 2024. It covers, vaccines, radiopharmaceuticals, ADCs, CAR-Ts, bi-specifics, & more.

Whitepaper

Developing and Manufacturing Drugs with HPAPIs

Discover how to effectively classify highly potent APIs and the steps required to develop containment protocols and manufacturing processes that are both safe and efficient.

eBook

7 “Make or Break” Factors for Emerging Biopharma Companies

This e-book explores 7 factors that are critical to the success of emerging biopharma companies, whether they plan to out-license, partner, or launch & commercialize products.  It’s an essential resource for emerging companies with products in all stages of development.
 

 

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