GSK, under pressure to perform, pens $2.2B deal with Alector focused on neuro R&D, Alzheimer's Acumen surges in first day of trading as it rides coattails of Biogen's Aduhelm approval, Lilly Alzheimer's developments Lundbeck sells off flopped Alzheimer's drug as Aduhelm approval ups interest Sponsored: The Far-Reaching Value of Deeply Understanding the Patient Journey Arrowhead slams brakes on early-stage cystic fibrosis study after rat study triggers lung inflammation concerns Roche vet leaves Nordic Nanovector 3 months after joining as CEO FDA finds faults in Iterum antibiotic filing with decision date looming Caribou eyes $100M IPO as it aims off-the-shelf CAR-Ts at the clinic Fierce15 winner Rallybio establishes proof-of-concept in phase 1/2 study for rare fetal bleeding disorder Eschewing an IPO (for now), Sirnaomics nabs a rare series E worth $105M for next-gen RNA work Parexel snapped up, again, as Goldman Sachs, EQT spend $8.5B on the CRO Astronauts perform first CRISPR gene-editing studies in space Regeneron pinpoints gene variants that protect against obesity, launches search for new drugs Chutes & Ladders—AstraZeneca internally promotes Galbraith to helm cancer R&D Fierce Pharma Asia—Fujifilm, WuXi STA plan major expansions; Hanmi's GLP-1 posts heart data; BeiGene plots $3B China IPO Featured Story | By Ben Adams GlaxoSmithKline is penning an upfront and biobucks combo deal worth up to $2.2 billion with Fierce 15 winner Alector in neurodegenerative diseases. read more |
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Top Stories By Kyle LaHucik Acumen Pharmaceuticals soared in its first day of trading on the Nasdaq as the company raised $160 million to bankroll its Alzheimer's candidate following Biogen's Aduhelm approval and Eli Lilly's plans to move toward an accelerated approval for its own drug for the disease. read more By Nick Paul Taylor Lundbeck has offloaded the rights to an Alzheimer’s disease drug candidate that failed three phase 3 clinical trials in 2016 and 2017. China’s Denovo Biopharma has picked up the global rights to the 5-HT6 receptor antagonist in a deal that gives Lundbeck the option to reacquire the asset down the line. read more Sponsored by: Alexion An experiential learning program where Alexion employees “walk in the shoes” of patients to deepen understanding of the rare disease journey and develop impactful solutions. Learn more about LEAP. read more By Annalee Armstrong Arrowhead Pharmaceuticals is pausing a phase 1/2 study for an RNAi therapeutic after rats in a preclinical study showed unexpected lung inflammation. The Pasadena, California-based biopharmaceutical company is developing ARO-ENaC to treat patients with cystic fibrosis. The therapy aims to reduce production in the lungs' airways of a protein associated with airway dehydration and reducing the transport of mucus in patients with the disease. read more By Nick Paul Taylor Peter Braun is leaving Nordic Nanovector three months after joining the company as CEO. Nordic Nanovector attributed Braun’s departure to “personal reasons” and named its chief financial officer to the top job on an interim basis. read more By Amirah Al Idrus Five months after hopping into the fast lane, Iterum’s oral antibiotic is hitting a roadblock. The FDA has stopped discussing labeling and postmarketing requirements thanks to “deficiencies” found in the drug’s application. The news came in a letter from the agency that did not detail what those deficiencies were, the company said in a statement on Thursday afternoon. read more By Amirah Al Idrus Another day, another $100 million. In a move that’s starting to look like a rite of passage in biotech, Caribou Biosciences filed on Thursday to raise $100 million in its Wall Street debut. The proceeds will propel three off-the-shelf CAR-T therapies into and through the clinic and boost Caribou’s work in natural killer (NK) cell therapies. read more By Annalee Armstrong 2018 Fierce15 winner Rallybio has established proof-of-concept for an antibody treatment aiming to prevent a rare disease that causes a mother’s immune system to attack her fetus or newborn child’s platelets. Rallybio is conducting a phase 1/2 study of RLYB211 to prevent Fetal and Neonatal Alloimmune Thrombocytopenia (FNAIT), which can cause uncontrollable bleeding in fetuses and newborns. read more By Ben Adams It’s a case of déjà vu (and no IPO) for the U.S.-China RNAi biotech Sirnaomics as it grabs a $105 million funding round, just under a year after grabbing the same amount in a D round. read more By Ben Adams The rumors were true: Whispers grew this year that Parexel, owned for the past four years by Pamplona Capital, was seeking a sale or an IPO. Today, the whispers stopped as the CRO loudly declared it is being bought out for $8.5 billion. read more By Amirah Al Idrus Aboard the International Space Station, astronauts used CRISPR to help zero in on how cells repair DNA that may be damaged by cosmic radiation. read more By Arlene Weintraub A team at Regeneron Genetics Center has discovered mutations in the gene GPR75 that protect against obesity. They showed in a new study that when they fed a high-fat diet to mice that were engineered to lack either one or two copies of the gene, the animals didn't gain nearly as much weight as normal mice did. Now, Regeneron is searching for drugs to target the gene. read more By Kyle LaHucik After 11 years working on cancer therapies at AstraZeneca, Susan Galbraith, Ph.D., has been named the Big Pharma's successor to the late José Baselga, who led cancer R&D. Former Sanofi research head Carlos Garcia-Echeverria, Ph.D., joins EQRx to lead drug discovery and creation for the in-licensed-focused biotech. And Moderna taps an Ogilvy executive as its first chief brand officer. read more By Angus Liu Fujifilm and WuXi STA are expanding their CDMO capacities in the U.S. Hanmi's GLP-1 diabetes drug, once partnered with Sanofi, showed it could reduce the risks of heart and kidney diseases. BeiGene has won clearance to stage a $3 billion IPO on China's Nasdaq-like STAR market. And more. read more | | Health Care Is Home Care From study drug administration to blood draws, Marken’s fully integrated home healthcare solutions make participation in clinical research as simple as possible for patients. Learn more. |
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