Where are 2012's Fierce 15 now?
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Bridgebank

Thank you to Bridge Bank for sponsoring our editorial feature: FierceBiotech 15 Where Are They Now?

Featured Story

ESC 2022: BMS, J&J's secondary stroke med falls short in phase 2, but companies see enough potential to push forward

A new interim analysis of Bristol Myers Squibb's anticoagulant milvexian as a treatment for secondary strokes shows a mixed bag of data. The drug failed its primary endpoint, but a reduction in stroke incidence among three dosing groups beat the company's expectations.

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Top Stories

ESC 2022: Bayer, like its rivals, hopes it made a big enough splash after phase 2 belly flop

Bayer's anticoagulant to prevent secondary strokes flopped a phase 2 trial, keeping in line with results from rivals BMS and J&J. The company reported that its med, asundexian, did not produce a dose-dependent reduction in the composite rate of covert brain infarction or ischemic stroke.

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Where are they now? Tracking down 2012's Fierce 15

It’s the 20th year we’ve sought out the most innovative private biotechs, which also means we've entered the second decade we've been checking in on our past honorees.

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Alnylam stays on Calliditas' heels as Regeneron-partnered nephropathy drug passes phase 2

Alnylam has reached a phase 2 checkpoint of its Regeneron-partnered immunoglobulin A nephropathy treatment as it looks to catch up with Calliditas Therapeutics' FDA-approved med Tarpeyo. 

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Invigorating T cells by crippling a gene to improve immunotherapies for blood and solid cancers

A research team led by scientists at the University of California, San Francisco has uncovered a gene involved in the regulation of T-cell immunity. Using CRISPR to inactivate the gene helped TCR and CAR T cells become more resilient and sensitive and prolonged survival in mice carrying either liquid or solid tumors.

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ESC 2022: AstraZeneca's Farxiga is first heart failure drug to show across-the-board mortality benefit

At the European Society of Cardiology’s annual meeting, AstraZeneca presented data that could boost Farxiga in the competitive heart failure market. It is the first heart failure drug to show it can reduce the risk of death in patients regardless of their ejection fraction status.

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Amazon Care shutdown is a strategic play, not a failure, some healthcare experts say

Forrester healthcare analysts called the shuttering of Amazon Care "a strategic move" rather than a failure. Amazon still has its sights set on primary care, many healthcare experts say, as it represents the gatekeeper of patient care.

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ESC 2022: Abbott’s heart pump boasts improved 5-year life expectancy for heart failure patients

A heart pump from Abbott may give at least five years back to severe heart failure patients, according to clinical trial results presented this week at the 2022 European Society of Cardiology Congress in Spain.

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Cigna to enter ACA exchanges in 3 more states for 2023

The expansion, which is pending regulatory approval, will bring Cigna's total ACA footprint to 363 counties across 16 states, the insurer said.

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Olympus inks $3B sale of scientific tools unit to private equity firm Bain Capital

After days of swirling speculation, Olympus finally confirmed this week that it has agreed to sell off its scientific solutions business to Bain Capital Private Equity.

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Whitepaper: The Most Suitable Dosage Form Technologies for the Oral Delivery of Lipid-Based Formulations

What is the most suitable dosage form technology for the Oral Delivery of Lipid-Based Formulations?

Article: Formulation Strategies When Transitioning From Vial to PFS

Learn how formulation development for a PFS affects manufacturing to drive the industry toward optimizing delivery of injectable products and, ultimately, improving patient care.

Whitepaper: Catalent Pulmonary & Nasal Delivery Capabilities Sheet

Did you know Catalent has newly expanded in-house capabilities spanning clinical and commercial scale manufacturing for DPIs, unit-dose, bi-dose and preserved multi-dose nasal sprays?

Whitepaper: Intranasal Drug Product Development: Formulation to Manufacturing

What are key considerations for intranasal delivery in the treatment of acute and chronic conditions?

Case Study: Versatility of Softgel Technology - Encapsulation of a Volatile Compound

Learn more about how the versatility of Softgel Technology helped a customer with a volatile compound.

Article: Lipid-Based Drug Delivery System to Bring Poorly Soluble Drugs to Market

How can Lipid-Based Drug Delivery System help bring poorly soluble drugs to market?

eBook: Orally Inhaled & Nasal Drug Delivery: A Pipeline of Opportunities

Carla Vozone discusses the significant trends in the OINDP segment including large molecules and novel indications, changes within CDMOs and various challenges facing the industry.

On-Demand Webinar: The Faster Path From Pre-Filled Syringe to Auto-Injector

Ypsomed and Catalent Biologics experts discuss strategies for integrated PFS manufacturing and auto-injector assembly to accelerate timelines and more in this webinar.

Events