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December 19, 2017

Today's Rundown

Featured Story

Genentech, DiCE ally to go after hard-to-drug targets

Genentech has entered into a multitarget drug discovery deal with DiCE Molecules. The Roche unit is handing over an upfront fee and committing to milestones to apply DiCE’s small molecule platform to targets of interest.

Top Stories

CDC denies word ban, says guidelines are limited to budget presentation

Furor erupted when reports emerged that the CDC was banning certain words and phrases from official budget documents. The agency's director denied the the existence of a ban, saying the guidelines were discussed in a budget-related meeting and should not be construed as "overall guidance."

Array Biopharma ties up with Pfizer on cancer-fighting combos

Array and Pfizer will collaborate on a phase 1b trial investigating combinations of Array's binimetinib and Pfizer's PARP inhibitor talazoparib and anti-PD-L1 med avelumab in non-small cell lung cancer and pancreatic cancer.

[Sponsored] Addressing Placebo Response, Therapeutic Misconceptions and Expectations

Randomized, placebo-controlled clinical trials are the most complex step in the development of new drugs. A contributor to trial failure is the increased rate of placebo response, which is now historically high. How can these trends be reversed?

Boehringer forges alliance with U.K. exosome specialist Evox

Germany’s Boehringer Ingelheim has entered into a deal with Evox Therapeutics, its second with a U.K.-based biotech in as many days.

[Sponsored] Managing Demand Uncertainty in Biologics Production

When a biologics company prepares to launch a new product, it must forecast the capacity it will need. Learn how to mitigate risks by developing a manufacturing strategy that will accommodate a forecast range and allow you to adapt as better data becomes available.

Roche pens neurological, developmental disorder drug discovery pact with Confo  

Roche has entered into a neurological and developmental disorder drug discovery pact with Confo Therapeutics. The agreement gives Roche a potential source of small molecule agonists of an undisclosed G-protein coupled receptor.

Founder of nonprofit lands at WuXi NextCODE for rare disease push

Christina Waters, Ph.D., founder and CEO of pediatric rare disease nonprofit Rare Science, joined genomics firm WuXi NextCODE as senior VP, focusing on bolstering its rare disease programs.

Zoll drives sleep apnea firm Respicardia to $59M round

Respicardia has rounded up $58.5 million to commercialize its sleep apnea device in the U.S. The Zoll Medical-led round comes two months after Respicardia secured FDA clearance to market its implantable neurostimulation system.

Resources

[Whitepaper] Accessing Scientific Literature Doesn’t Have To Be Like Scaling A Mountain

SO CLOSE AND YET SO FAR. Is that how many documents seem to you? Getting what you want—when, where, and how you want it—can be a real pain. That’s why we created this concise guide to getting around the obstacles that stand between you and the information your organization needs. Download the whitepaper to learn more.

[Whitepaper] Choosing the Right Solution: Improving the Site Feasibility Process

Selecting the right sites to conduct your clinical trials will determine the success or failure of meeting your enrollment goals.

[Whitepaper] How biopharma companies are bolstering R&D pipelines through deal-making

Sourcing research externally seems to be the preferred path for biopharma companies to strengthen their R&D pipeline.

[Whitepaper] 5 Steps to Managing Quality Globally

Read this guide if you’re a global life sciences company - conducting clinical trials across several countries, or manufacturing and distributing products in multiple regions - to learn five steps to align and improve quality oversight, as well as avoid common mistakes in harmonization initiatives.

[Whitepaper] Growing Regulatory’s Strategic Value: The Value of a Holistic RIM Capability

Read Deloitte Consulting's whitepaper on the value of a holistic RIM capability, covering the potential cost savings and revenue gains from doing RIM right.

[Whitepaper] How Do Sponsors Ensure Quality in Global Clinical Trials?

Global clinical trials are the trend and gaining in popularity, but running a global trial is not a straightforward process. This white paper explores some of the challenges associated with global clinical trials and considerations for ensuring that the collected data comply with the trial's overall objectives.

[Whitepaper] DSM Looks to Challenge Traditional Stent Graft Materials with its Dyneema Purity® Membrane Edit

Discover DSM's Dyneema Purity® membrane, an effective and efficient material to construct stent grafts used in minimally invasive surgeries to treat both cardiovascular and peripheral arterial diseases.

[Webinar] Validating a 7 Day Membrane Filtration Sterility Test using Celsis®

Join us as we discuss how Charles River Celsis® helped Labor L+S AG validate a 7-day membrane filtration sterility test using existing protocols.

[Infographic] Evolution of Flexible Commercial Biologics Manufacturing

Learn how Catalent Biologics is paving the way for flexible biologics development and manufacturing through advanced technologies and fully integrated multi-product facility.

[eBook] Developing Site-specifically Modified ADCs: Using a Chemoenzymatic Approach

Download the eBook to get articles from various Elsevier journals highlighting developments in ADC technology.

[Article] Optimizing titer and use of a specific enzyme for generating a fully processed antibody

Learn how cell development and process scale-up can be optimized for antibodies requiring additional processing.

[Webinar] Within-Subject Clinical Trials: Intro to New Methods & Stat. Models

In this webinar, we will introduce the rapidly-evolving within-subject clinical trial (WSCT) methods for early phase evidence generation that require fewer people, less time, and usually less funding than traditional early phase methods.

Events

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