| Editor’s note: Please enjoy our top 10 stories of the year issue, plus your normal news. We will now take a publishing break until Jan. 2.
Today's Rundown FierceBiotech's top 10 stories of 2019—Gilead's failure, Biogen's phoenix, JPM venue fatigue and more Gilead rocked by phase 3 failure of selonsertib in NASH Biogen resurrects aducanumab, arguing expanded data set supports FDA filing in Alzheimer's [Sponsored] Invitae’s Detect Programs Breakdown Barriers to Genetic Testing Attendees fed up with venue, high prices call to move JPM out of San Francisco Celgene posts pivotal CAR-T data ahead of FDA filing Roche's effort to stop cancer metastasis unexpectedly leads to a Merck drug Eli Lilly to shutter neuroscience R&D center next year Novartis strikes $9.7B takeover of The Medicines Company Gilead drops anti-BCMA CAR-T from Kite, takes $820M charge As Celgene becomes BMS, its I&I lead lands CEO job at Takeda spinoff Biogen hit by 'transformative failure' as it cans aducanumab tests Roche to pay Sarepta $1B upfront for DMD gene therapy rights News of Note—J&J buys up drug delivery biotech; AstraZeneca out licenses asset; NASH biotech cancels IPO Featured Story | | | Monday, December 23, 2019 As we reach the end of the year, we look back on the most read stories of the last 12 months as we also look ahead not just to a new year, but a new decade. So, what were the most read stories that you, dear reader, sought to end the 2010s with? |
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Top Stories Tuesday, February 12, 2019 A phase 3 trial of Gilead’s NASH prospect selonsertib has bombed. The ASK1 inhibitor was no better than placebo at improving fibrosis, wiping out hopes that selonsertib would spearhead Gilead’s push into a new market. Tuesday, October 22, 2019 Biogen is planning to file for FDA approval of its failed Alzheimer’s disease drug aducanumab. The drug flunked a futility analysis in March, but Biogen resurrected it after factoring in data generated after the cutoff for the interim assessment. Thursday, December 19, 2019 Lack of access to genetic testing delays diagnosis and limits access to clinical trials and approved therapies. Sponsored testing programs can help. Tuesday, January 15, 2019 While the high cost of living in San Francisco has famously grabbed headlines, the costs of simply meeting there, even for a few days, are becoming untenable for some. Thursday, November 7, 2019 Celgene has posted data from a pivotal trial of its CAR-T therapy. The data look competitive against Gilead’s Yescarta and Novartis’ Kymriah, leading analysts to predict Celgene will win FDA approval next year. Thursday, August 22, 2019 Researchers at Roche and the Paul Scherrer Institute have identified a way to prevent the spread of certain cancer cells. Then they discovered that Merck already has a drug in development that may accomplish that feat. Tuesday, October 15, 2019 Eli Lilly is closing down its U.K.-based Erl Wood neuroscience in Surrey, leading to cuts and relocations. Monday, November 25, 2019 Novartis has agreed to a $9.7 billion (€8.8 billion) deal to buy The Medicines Company for inclisiran. The takeover represents a big bet that the near-approval cholesterol drug will perform better commercially than rival medicines sold by Amgen and Regeneron and Sanofi. Tuesday, February 5, 2019 Buried in among Gilead’s fourth-quarter results statement is a line revealing it has abandoned an anti-BCMA cell therapy for multiple myeloma, part of its $12 billion acquisition of Kite Pharma. Friday, September 27, 2019 As Celgene gradually phases into parent company Bristol-Myers Squibb, this is leaving little room at the inn for some of the top execs. Thursday, March 21, 2019 Biogen and partner Eisai are throwing in the towel on late-stage tests for their key Alzheimer’s drug as independent experts reveal that it just won't make the grade. Monday, December 23, 2019 Roche is paying more than $1 billion upfront for the ex-U.S. rights to Sarepta's Duchenne muscular dystrophy gene therapy SRP-9001. The deal comes days after Roche advanced its push into gene therapies by closing the takeover of Spark Therapeutics. Monday, December 23, 2019 Our final roundup of biotech news for the year, and the decade. Resources Sponsored by: Outer Edge Technology, LLC Why companies leverage the expertize of industry focused cloud service providers to design and build quality systems and facilitate the FDA Validation of Mission Critical Apps in the Cloud. Sponsored by: Colorcon Learn more: Best practices for defending supply chain security and compliance by efficiently managing product authentication. Sponsored by: Metabolon Small or emerging pharmaceutical and biotech companies pursuing novel molecules and targets have two important goals: achieve clinical success and attract new rounds of funding. While there’s never a guarantee of either, certain actions can influence the outcome in your favor. Sponsored by: Catalent Learn how recent innovations in demand-led supply and direct-to-patient distribution are converging to create a next-generation clinical supply chain that is flexible, lean and most importantly patient-centric. 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Sponsored by: Amazon Web Services From IoT to data management to high-performance computing and machine learning, leading life sciences organizations are using Amazon Web Services (AWS) to develop scalable, global, predictable, and secure solutions to modernize clinical trials while mitigating risks Sponsored by: Eli Lilly and Company in partnership with Xcenda Download this complimentary paper that explores the practice of step therapy and its impact on key stakeholders in the US healthcare system. Asia-Pacific Healthcare Compliance Certificate Program March 9-12, 2020 FierceBiotech Executive Breakfast at the J.P. 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