| Transcriptional activity within a call can be used to evaluate cell response to a ligand or promoter activity. Catalent has developed a relative potency bioassay using real-time quantitative reverse transcription (RT-qPCR) in a duplex format to assess relative transcription activity in cells treated with ligands or transgenic vectors. |
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| Watch this on-demand webinar to learn about the potency bioassay using RT-qPCR to assess relative transcription activity, the advantages and disadvantages of the assay compared to reporter gene assays and assays used for the analysis of cell and gene therapies. |
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| | | Exploring New and Improved Analytical Methods for Traditional and Unique Modalities |
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| Biophysical characterization is critical to understand the make-up and behaviors of biologic therapies and vaccines, both early in development and throughout the manufacturing scale-up process. As biologics become more complex in structure, and as scientists improve their understanding of the effects of structure on stability, efficacy, safety, etc., there is a need to develop new and improved analytical methods to characterize biologic products. |
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| Watch this on-demand webinar to learn about a method to evaluate extractables and leachables in order to measure residual-free toxins during antibody-drug conjugate (ADC) development and common techniques used to identify, characterize and quantitate sialic acids on biologics. |
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