Featured Story | By Kyle Blankenship AstraZeneca set the tone for the future of SGLT2 diabetes medicines in May with Farxiga's heart-helping FDA approval in patients with or without diabetes. Now, the company is looking to change the game again in kidney disease—and outcomes data from a halted pivotal study certainly adds some heft. read more |
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Top Stories By Kyle Blankenship AstraZeneca put the rest of the SGLT2 inhibitor class on notice when its Farxiga scored an FDA heart failure nod in patients with or without diabetes. One of its competitors, Eli Lilly and Boehringer Ingelheim's Jardiance, is fast on Farxiga's heels, though, and it's ready to bring its pivotal trial win in front of physicians. read more By Conor Hale A phase 3 pivotal trial of MyoKardia's mavacamten has demonstrated that the first-in-class drug can perform as a disease-specific therapy for hypertrophic cardiomyopathy, or HCM, by preventing the thickened heart muscle associated with the disease from obstructing the flow of blood. read more By Kyle Blankenship As the bestselling drug in the heart failure space, Novartis' Entresto suffered a stinging setback last year in a novel indication—but there were some signs of hope. Now, a new Entresto study is again showing promise in that patient population, but it's not a resounding win. read more By Conor Hale Despite pandemic-related setbacks in its clinical program earlier this year, Novartis has continued to stack up favorable data for its cholesterol drug inclisiran—with a new analysis showing that 99% of treated patients cut their LDL levels by 30% or more. read more By Kyle Blankenship With its blockbuster hopes in question after a catastrophic patent loss, Amarin's Vascepa continues to pique investigators' interest over how exactly it cuts patients cardiovascular risks. New data from an investigator-sponsored imaging study could provide a clue. read more By Kyle Blankenship Amgen's Repatha and Sanofi and Regeneron's Praluent have been locked in a heated battle for supremacy in the pricey PCSK9 cholesterol-cutting market. Looking to angle its way to an advantage, Amgen is looking to adolescent patients with a rare disorder causing high cholesterol levels. read more By Kyle Blankenship Late to the party against its SGLT2 diabetes rivals, Merck & Co.'s Steglatro has also tracked way behind in the class' growing presence in heart failure. Now, the drugmaker has posted new data showing Steglatro could, in fact, show benefits in that indication—but it's a limited window into the future. read more By Conor Hale Researchers have shown it may be possible to detect potentially severe heart damage in less than 10 minutes using only a saliva sample, and they're aiming to build a tailor-made test to do it. read more By Kyle Blankenship Pfizer and Bristol Myers Squibb's anticoagulant superstar Eliquis has raced out to blockbuster sales in recent years and a big-time lead over its its warfarin alternative competitors. Looking to pad that lead, the partners are building a body of real-world evidence for their drug, and in one French study the results are mostly promising. read more | 