| Long-term use of metformin in DPPOS was associated with biochemical B12 deficiency and anemia. Routine testing of vitamin B12 levels in metformin-treated patients should be considered (JCEM)
In this study, we explored the relationship between hBAT and glucose metabolism in a series of whole-body and in vitro studies in humans. We hypothesized that hBAT regulates glucose fluxes and plays a determinative role in whole-body glucose homeostasis (Cell Metabolism)
Systematic acquisition of information about diabetes care can be analyzed, extrapolated, and then used to provide a core set of actionable recommendations that may be further studied and implemented to improve diabetes care on a global scale (Annals of Global Health)
The National Diabetes Inpatient Audit is a snapshot audit of diabetes inpatient care. In September 2015 the National Diabetes Inpatient Audit was conducted in hospitals across England and Wales, collecting data on characteristics of the hospital including staffing structures, patient clinical data and patient experience information (HSCIC)
Hypokalemia occurs frequently during acute DKA management and is often preventable. Our findings suggest that interventions targeted at enhancing awareness of guidelines may reduce hypokalemia rates (Canadian Journal of Diabetes)
This study confirms that long-lasting hyperglycemia in type 1 diabetes induces a permanent alteration which contributes to maintaining endothelial dysfunction even when glycemia is normalized, and that in the presence of normoglycemia, GLP-1 can contribute to normalizing endothelial function (Diabetes Research and Clinical Practice)
In this review, we focus on the FOXO1 pathway and its role in various processes that have been related to DCM, such as metabolism, oxidative stress, endothelial dysfunction, inflammation and apoptosis (Cardiovascular Diabetology)
For the majority of older adults, an HbA1c target between 7.5% and 9% will maximize benefits and minimize harms (JAMA)
In this retrospective cohort study of a large sample of primary care patients with type 2 diabetes, ADM use was associated with improved glycaemic control (Family Practice)
Despite no difference in absolute LDL levels, subjects with type 2 diabetes were more likely to have small, dense LDL particle pattern and lower total HDL, HDL-2, and HDL-3 fractions. Furthermore, coalescence of obesity, poor glycemic control and dyslipidemia, particularly in patients with type 2 diabetes, may accelerate CVD progression early in life(Diabetes Research and Clinical Practice)
Differences in initial insulin dosage produced different BG dynamics in wk 1, equivalent BG dynamics on wk 2 and 3, but had no influence on short- and long-term BG control and honeymoon phase. The wide range of initial insulin dosage could be chosen if guided by BG monitoring (Pediatric Diabetes)
Metformin use is an independent determinant of increased colonic 18F-FDG uptake, suggesting a potential role for increasing colonic glucose disposal (Diabetes Research and Clinical Practice)
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