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Cell-based assays are used to facilitate the analysis of complex cellular functions and understand their impact on disease onset and development, as well as to enable pathway-specific drug screening.

Researchers supported by the National Institutes of Health developed a new technique that combines complimentary methods to help reconstruct reference genomes with high accuracy.

Metabolic measurement of humans and animal models is an important aspect of biomedicine. However, the limitations of current methods in metabolic measurement are not widely understood. This mini-review explains the methodological trade-offs involved in metabolic measurement with flow-through respirometry and specifically addresses limitations regarding temporal resolution and accuracy of metabolic measurement systems with practical solutions.

It sounds like science fiction, but a cap-like device that makes electric fields to fight cancer improved survival for the first time in more than a decade for people with deadly brain tumors, final results of a large study suggest.

Due to an increase in the abuse of synthetic insulins, doping laboratories require faster and more consistent testing options. The methodology to detect and confirm the presence of peptide hormones by mass spectrometry is preferred to the current use of immunoassays or other immuno-reactive techniques. This white paper explores and compares the different available methods, revealing the fastest and most accurate options for synthetic insulin detection.

Rubbery, multifunctional fibers could be used to study spinal cord neurons and potentially restore function.

Antibiotics save lives every day, but there is a downside to their ubiquity. High doses can kill healthy cells along with infection-causing bacteria, while also spurring the creation of "superbugs" that no longer respond to known antibiotics. Now, researchers may have found a natural way to cut down on antibiotic use without sacrificing health: a maple syrup extract that dramatically increases the potency of these medicines.

Metabolic reprogramming is a major cancer hallmark characterized by the upregulation of a number of pathways providing tumor cells with vital energy and metabolites. Metabolic plasticity allows cancer cells to adapt to changing conditions of the tumor microenvironment, enabling rapid growth, proliferation, invasion, metastasis, and resistance to anti-cancer therapies.

Genetic testing of tumor and blood fluid samples from people with and without one of the most aggressive forms of skin cancer has shown that two new blood tests can reliably detect previously unidentifiable forms of the disease.

U.S. health officials have begun enrolling volunteers for critical next-stage testing of an experimental vaccine to protect against Zika, the mosquito-borne virus that can cause devastating birth defects in pregnant women.