| Helene M. Langevin, M.D. February 24, 2022 Pragmatic trials are an essential avenue for understanding how interventions can impact the health outcomes of people. Complementing the scientific value and strengths of randomized controlled trials (RCTs), pragmatic trials offer insights into what happens when patients step out of the well-controlled parameters of RCTs and into the real world. The work to advance the rigor and use of pragmatic trials hit an important milestone earlier this year. What began 10 years ago as a National Institutes of Health (NIH) Common Fund initiative, the NIH Health Care Systems Research Collaboratory has graduated out of the Common Fund and recently been renamed the NIH Pragmatic Trials Collaboratory. The Collaboratory will continue to be led by the National Center for Complementary and Integrative Health (NCCIH) and the National Institute on Aging, with the support of a dozen Institutes and Centers across NIH, as well as the Helping to End Addiction Long-term Initiative, or NIH HEAL Initiative. | 