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| Abundant ‘secret doors’ on human proteins could reshape drug discovery Posted: 06 Apr 2022 10:24 AM PDT A groundbreaking new technique reveals the existence of a multitude of previously hidden therapeutic targets that control protein function and which could, in theory, be targeted to dramatically change the course of diseases as varied as dementia, cancer and infectious diseases. The approach, which finds that the 'secret doors' are abundant and identifiable, could be a game changer for drug discovery, leading to safer, smarter and more effective medicines. It enables research labs around the world to find and exploit vulnerabilities in any protein -- including those previously thought 'undruggable'. |
| Scientists pinpoint what makes brain cells develop in a specific order Posted: 06 Apr 2022 10:24 AM PDT Researchers have identified the complete series of 10 factors that regulate the development of brain cell types in the visual system of fruit flies -- including in what order these neurons develop. The findings open new avenues of research to understand how brain development evolved in different animals and hold clues for regenerative medicine. |
| Brain charts map the rapid growth and slow decline of the human brain over our lifetime Posted: 06 Apr 2022 10:24 AM PDT An international team of researchers has created a series of brain charts spanning our entire lifespan -- from a 15 week old fetus to 100 year old adult -- that show how our brains expand rapidly in early life and slowly shrink as we age. The charts are the result of a research project spanning six continents and bringing together possibly the largest ever MRI datasets ever aggregated -- almost 125,000 brain scans from over a 100 different studies. Although not currently intended for clinical use, the team hopes the charts will become a routine clinical tool similar to how standardised paediatric growth charts are used. |
| Hubble probes extreme weather on ultra-hot Jupiters Posted: 06 Apr 2022 10:24 AM PDT Astronomers have discovered bloated Jupiter-sized worlds that are so precariously close to their parent star they are being roasted at seething temperatures above 3,000 degrees Fahrenheit. That's hot enough to vaporize most metals, including titanium. They have the hottest planetary atmospheres ever seen. Hubble astronomers are reporting on bizarre weather conditions on these sizzling worlds. It's raining vaporized rock on one planet, and another one has its upper atmosphere getting hotter rather than cooler because it is being 'sunburned' by intense ultraviolet (UV) radiation from its star. |
| Study examines if there is something 'fishy' happening with seafood imports Posted: 06 Apr 2022 07:18 AM PDT Reducing tariffs on imported goods is meant to remove trade barriers, but it doesn't seem to be helping the seafood industry, which has experienced the same -- if not more -- import rejections and notifications at borders, according to research guided by an agricultural economist. The study, which explored tariff and nontariff barriers in the seafood trade, also documented the reasons for products held at the borders. |
| The road to popularity can be paved with unpleasantness Posted: 06 Apr 2022 07:18 AM PDT A longitudinal study tested the novel hypothesis that aggressive and disruptive children engage in frequent conflicts with classmates to strengthen their position in the group and enhance their popularity. Results revealed that higher initial levels of peer-reported aggression and disruptiveness were associated with increases in peer-reported popularity over the course of a semester, particularly for children who reported frequent disagreements with peers. |
| Injectable microtissue preserves muscle function in rats with severed sciatic nerves Posted: 06 Apr 2022 07:18 AM PDT Researchers engineered the first injectable microtissue containing motor and sensory neurons encased in protective tissue, called tissue engineered neuromuscular interfaces (TE-NMIs). The TE-NMI neurons provide a source of axons to muscles in rats who suffered nerve injuries, and 'babysit' the muscles to prevent degeneration and loss of function, while the damaged nerve regrows. |
| Posted: 06 Apr 2022 07:17 AM PDT A new study has shown that a specialized primary care medical home improved the care and treatment of patients with serious mental illness, resulting in better mental health-related quality of life. |
| Touchy subject: 3D printed fingertip 'feels' like human skin Posted: 06 Apr 2022 07:17 AM PDT A highly sensitive, 3D-printed fingertip could help robots become more dexterous and improve the performance of prosthetic hands by giving them an in-built sense of touch. |
| 'Robot scientist' Eve finds that less than one third of scientific results are reproducible Posted: 06 Apr 2022 07:17 AM PDT Researchers have used a combination of automated text analysis and the 'robot scientist' Eve to semi-automate the process of reproducing research results. The problem of lack of reproducibility is one of the biggest crises facing modern science. |
| Like college roommates, vampire bats bond when randomly paired Posted: 06 Apr 2022 07:17 AM PDT Social bonding between randomly assigned college roommates is not only a human phenomenon, a new study on vampire bats suggests. Vampire bat pairs that were forced to live together for only one week sustained their friendly relationships for more than two months after they were released into a bigger bat community. |
| New link between greenhouse gasses and sea level rise Posted: 06 Apr 2022 07:17 AM PDT Researchers have used advanced ocean modelling techniques to reveal how greenhouse gas emissions contribute to warmer oceans and resulting melting of the West Antarctic Ice Sheet. |
| With a whiff, 'e-nose' can sense fine whisky Posted: 06 Apr 2022 07:17 AM PDT Researchers have developed an e-nose that can distinguish different types of whisky. |
| How multiple genes impact vision development and result in rare sight disorder Posted: 06 Apr 2022 07:17 AM PDT An international team of health researchers have described how genetic defects influence the spectrum of vision development and cause problems in developing babies' eyes. |
| High performance microscopy for non-invasive conjunctival goblet cell examination Posted: 06 Apr 2022 07:17 AM PDT Scientists have developed a high-speed extended depth-of-field (DOF) microscopy for non-invasive conjunctival goblet cell (CGC) examination. |
| Simulations explain Greenland’s slower summer warming Posted: 06 Apr 2022 07:17 AM PDT Climate changes in the tropical Pacific have temporarily put the brakes on rapid warming and ice melting in Greenland. |
| Neolithic made us taller and more intelligent but more prone to heart disease Posted: 06 Apr 2022 07:17 AM PDT After the Neolithic, European populations showed an increase in height and intelligence, reduced skin pigmentation and increased risk of cardiovascular disease due to genetic changes that lowered concentrations of 'good' HDL cholesterol. The changes reflect ongoing evolutionary processes in humans and highlight the impact the Neolithic revolution had on our lifestyle and health. Research of these past events offers interesting starting points for today's science and health care. |
| Biodegradable gel boosts immune system's attack on several cancers in mice Posted: 06 Apr 2022 07:17 AM PDT The gel, tested in mice, releases drugs and special antibodies that simultaneously deplete immune-blocking cells called macrophages from the surgical site and activate T cells so they can attack cancer. |
| Century-old malaria parasite puzzle solved as ape origin traced Posted: 06 Apr 2022 07:16 AM PDT Scientists have solved a 100-year-old mystery about the evolutionary links between malaria parasites that infect humans and chimpanzees. |
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