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Researchers identify cells causing neuronal death in a mitochondrial disease animal model Posted: 08 Jul 2022 06:56 AM PDT Microglia, a type of central nervous system cell, is primarily responsible for neuronal death in Leigh Syndrome and the neurological symptoms related to this mitochondrial disease, according to a new study carried out in a mouse model. |
Functioning of antibodies in autoimmune encephalitis deciphered Posted: 08 Jul 2022 06:56 AM PDT Using a state-of-the-art method, researchers have succeeded for the first time at unraveling the effects of autoimmune antibodies, that are directed against the brain, in detail at the atomic level. To this end, they studied two antibodies that dock to so-called GABA-A receptors in one variant of autoimmune encephalitis. Their findings on the structural mechanisms are an important step towards the development of effective therapies -- and they also pave the way for further promising investigations using the new method. |
Online art viewing can improve well-being Posted: 08 Jul 2022 06:56 AM PDT Viewing art while visiting galleries and museums can have powerful effects on an individual's mood, stress and well-being. But does the same hold true for viewing art in digital space? A new study investigated whether engaging with art online also has this effect. Their conclusion: a short three-minute visit to an online art or cultural exhibition also shows significant positive effects on subjective well-being. |
Long term high-fat diet expands waistline and shrinks brain Posted: 07 Jul 2022 07:40 PM PDT New research shows that fatty foods may not only be adding to your waistline but may also be aggravating Alzheimer's disease, and causing depression and anxiety. |
Balancing protein in your diet could improve water quality Posted: 07 Jul 2022 02:18 PM PDT Balancing how much protein you eat with the amount your body needs could reduce nitrogen releases to aquatic systems in the U.S., a new study found. |
Posted: 07 Jul 2022 02:18 PM PDT Researchers found that high dose nitric oxide given to pregnant women with severe COVID-19 pneumonia resulted in reductions in the need for supplemental oxygen as well as in hospital and ICU lengths of stay, with no adverse events reported in mothers or newborns. |
How sound reduces pain in mice Posted: 07 Jul 2022 11:24 AM PDT Scientists have identified the neural mechanisms through which sound blunts pain in mice. The findings could inform development of safer methods to treat pain. |
Familiarity breeds exempt: Why staph vaccines don't work in humans Posted: 07 Jul 2022 11:23 AM PDT Researchers say they may have found the reason why multiple human clinical trials of staphylococcus vaccines have failed: the bacteria knows us too well. |
Gestures can improve understanding in language disorders Posted: 07 Jul 2022 11:19 AM PDT When words fail, gestures can help to get the message across -- especially for people who have a language disorder. An international research team has now shown that listeners attend the gestures of people with aphasia more often and for much longer than previously thought. This has implications for the use of gestures in speech therapy. |
Rising tide in adverse drug reactions Posted: 07 Jul 2022 11:19 AM PDT Researchers have identified an increasing trend in medicine-related harm leading to hospital admission. |
Parkinson's disease: Copper leads to protein aggregation, study finds Posted: 07 Jul 2022 11:19 AM PDT Copper exposure in the environment and the protein alpha-synuclein in the human brain could play an important role in the pathogenesis of Parkinson's disease. Researchers were able to show how the protein takes on an unusual shape when exposed to large amounts of copper ions. The findings could help develop new strategies for the treatment of neurodegenerative diseases. |
Nanoparticle 'backpacks' restore damaged stem cells Posted: 07 Jul 2022 11:18 AM PDT Bioengineers have shown that a new strategy can restore damaged stem cells and enable them to grow new tissues again. The new drug delivery system could help infants born from complicated pregnancies. |
Scientists use mini-kidney models to identify potential drugs for polycystic kidney disease Posted: 07 Jul 2022 11:18 AM PDT Scientists hsve generated simple kidney-like structures called organoids and used them to identify potential drugs to treat adult-onset polycystic kidney disease. To accelerate the quest for new treatments for ADPKD, researchers used pluripotent stem cells to grow organoids consisting of one or two structures resembling the kidney's filtering units, known as nephrons. To make the organoids useful for studying ADPKD, the scientists used CRISPR/Cas9 gene editing to inactivate PKD1 or PKD2. As anticipated, the gene-edited organoids began to form cysts. After testing a collection of 247 enzyme inhibitor compounds on the organoids, the scientists found nine that inhibited the growth of the cysts, without stunting the overall growth of the organoids. One compound, quinazoline, was particularly effective. |
Mouse study links changes in microbiome to prenatal opioid exposure Posted: 07 Jul 2022 11:18 AM PDT Researchers identified significant changes to the infant gut microbiome of mice associated with maternal exposure to oxycodone, a commonly used and abused opioid. |
The beginning of life: The early embryo is in the driver's seat Posted: 07 Jul 2022 11:18 AM PDT One often thinks that the early embryo is fragile and needs support. However, at the earliest stages of development, it has the power to feed the future placenta and instructs the uterus so that it can nest. Using 'blastoids', in vitro embryo models formed with stem cells, scientists have shown that the earliest molecular signals that induce placental development and prepare the uterus come from the embryo itself. |
Awash in potential: Wastewater provides early detection of SARS-CoV-2 virus Posted: 07 Jul 2022 11:18 AM PDT Scientists and physicians describe how wastewater sequencing provided dramatic new insights into levels and variants of SARS-CoV-2 on campus and in the broader community -- a key step to public health interventions in advance of COVID-19 case surges. |
Scientists hijack bacteria to ease drug manufacturing Posted: 07 Jul 2022 11:18 AM PDT For more affordable, sustainable drug options than we have today, the medication we take to treat high blood pressure, pain or memory loss may one day come from engineered bacteria, cultured in a vat like yogurt. And thanks to a new bacterial tool, the process of improving drug manufacturing in bacterial cells may be coming sooner than we thought. |
Posted: 07 Jul 2022 11:17 AM PDT In a new paper, researchers challenge the longstanding view that the force of natural selection in humans must decline to zero once reproduction is complete. They assert that a long post-reproductive lifespan is not just due to recent advancements in health and medicine. The secret to our success? Our grandparents. |
Alzheimer's disease biomarkers can predict postoperative delirium Posted: 07 Jul 2022 10:37 AM PDT A new study in patients reveals that two newly identified plasma biomarkers of Alzheimer's disease can predict postoperative delirium, one of the most common postoperative complications in older patients. The findings indicate the potential overlap between the mechanisms that cause Alzheimer's disease and postoperative delirium. |
'You are what you eat,' and now researchers know exactly what you're eating Posted: 07 Jul 2022 10:36 AM PDT Researchers describe a new method to identify all of the unidentified molecules derived from food, providing a direct way to link molecules in diet to health outcomes. |
Rheumatic fever and household overcrowding Posted: 07 Jul 2022 07:09 AM PDT Research has uncovered strong evidence that household overcrowding is a major risk factor for acute rheumatic fever and streptococcal infections of the skin. |
Researchers discover brain pathway that helps to explain light's effect on mood Posted: 07 Jul 2022 07:09 AM PDT Improved understanding of a neural pathway connecting light-sensitive cells in the retina with the cortical brain regions involved in mood and cognition has implications for the development of treatments for mood disorders. |
Climate factors predict future mosquito activity Posted: 07 Jul 2022 07:09 AM PDT Increases in three climate factors -- temperature, rainfall, and ocean warming -- predicted mosquito population growth in Sri Lanka for the next one to six months, according to a new study. The findings can inform the design and timing of programs to limit the spread of mosquito-borne diseases like dengue. |
Understanding how microbiota thrive in their human hosts Posted: 07 Jul 2022 07:09 AM PDT Scientists have made substantial progress in understanding how gut bacteria succeed in their human hosts on a molecular level. They investigated how bacteria produce inositol lipids, substances vital for many cellular processes in humans and other eukaryotes but hitherto rarely observed in bacteria. The results indicate that inositol lipids have implications for the symbiosis between the bacteria and their hosts. |
Social interactions tied to sense of purpose Posted: 07 Jul 2022 07:09 AM PDT Research in psychological and brain sciences shows a link in older adults between social interactions and having a sense of purpose. |
Posted: 07 Jul 2022 07:09 AM PDT Intermittent fasting has previously shown to have a host of health benefits, including lowering the risk of diabetes and heart disease. Now, researchers have found that people who regularly fast are less like to experience severe complications from COVID-19. |
Study examines memory in expert birdwatchers Posted: 07 Jul 2022 07:09 AM PDT According to a new study that examined memory in expert birdwatchers, having expert knowledge in a subject helps us memorize new information. This is because, while forgetting often happens when similar memories interfere with each other, expert knowledge provides a mental organizational structure, or scaffolding, that helps us keep new items that we want to learn distinct from each other. This reduces confusion between similar items -- in this case, similar-looking birds. |
Thyroid problems linked to increased risk of dementia Posted: 06 Jul 2022 01:54 PM PDT Older people with hypothyroidism, also called underactive thyroid, may be at increased risk of developing dementia, according to a new study. The risk of developing dementia was even higher for people whose thyroid condition required thyroid hormone replacement medication. |
Researchers decode retinal circuits for circadian rhythm, pupillary light response Posted: 06 Jul 2022 01:54 PM PDT The eye's light-sensing retina taps different circuits depending on whether it is generating image-forming vision or carrying out a non-vision function such as regulating pupil size or sleep/wake cycles, according to a new mouse study. |
Gardening can cultivate better mental health Posted: 06 Jul 2022 01:54 PM PDT New research suggests that many people may indeed reap mental health benefits from working with plants -- even if they've never gardened before. |
Study shows increase in COVID-19 vaccine acceptance around the world Posted: 06 Jul 2022 01:53 PM PDT COVID-19 vaccine acceptance increased 3.7% between 2020 and 2021, according to a new study. In a June 2021 survey of over 23,000 individuals across 23 countries, the researchers found that more than three-quarters (75.2%) of respondents reported vaccine acceptance, up from 71.5% one year earlier. |
After facial feminization surgery, transgender people report better psychosocial health Posted: 06 Jul 2022 01:53 PM PDT A new study offers evidence that transgender patients who receive gender-affirming facial feminization surgery reported better mental health after their procedures. |
Researchers create VX neurotoxin detector Posted: 06 Jul 2022 01:53 PM PDT Researchers are advancing the field of molecular detection by developing proteins that can detect a deadly nerve agent called VX in real-time and without false positives from insecticides. |
New study sheds light on why opioids can cause gastrointestinal problems Posted: 06 Jul 2022 01:53 PM PDT Opioids are the gold standard for treatment of chronic and acute pain; however, their use may result in significant gastrointestinal side effects, including nausea, vomiting, and constipation. The reasons behind these side effects are not well understood. A new study reports on how opioids like morphine cause gastric inflammation and how this condition can be reversed through treatment with proton pump inhibitor drugs like omeprazole, an over-the-counter medication commonly used to reduce stomach acid. |
Depression in fathers and children linked, regardless of genetic relatedness Posted: 06 Jul 2022 12:30 PM PDT Adolescent depression and behavior problems are on the rise and paternal depression may be contributing to this increase, regardless of whether the fathers and children are genetically related, according to new research. |
Solving algorithm 'amnesia' reveals clues to how we learn Posted: 06 Jul 2022 12:30 PM PDT A discovery about how algorithms can learn and retain information more efficiently offers potential insight into the brain's ability to absorb new knowledge. The findings could aid in combating cognitive impairments and improving technology. |
Helping teens channel stress, grow in resilience Posted: 06 Jul 2022 12:30 PM PDT The mental health crisis among teens has prompted an urgent quest for preventive interventions. Researchers believe they have one. As the team explains in a recent study, the 30-minute online training module teaches teenagers to channel their stress responses away from something negative that needs to be feared and tamped down towards recognizing those responses -- sweaty palms, a racing heart, for example -- as a positive driving force. |
Safety first: How stigma may impact health Posted: 06 Jul 2022 12:30 PM PDT Lack of safety, according to a new theory, may have a direct impact on the health of people in marginalized communities, particularly the LGBTQ community. The theory challenges decades of thinking that health disparities in the LGBTQ community are primarily due to encounters with stressful and discriminatory events, a concept called 'minority stress.' |
Death of a family member may increase heart failure mortality risk Posted: 06 Jul 2022 12:30 PM PDT Heart failure patients experiencing grief or in mourning following the loss of a close family member are at an increased risk of death, particularly during the first week following the family member's death, according to a new study. |
Imaging solves mystery of how large HIV protein functions to form infectious virus Posted: 06 Jul 2022 12:30 PM PDT Scientists have determined the molecular structure of HIV Pol, a protein that plays a key role in the late stages of HIV replication, or the process through which the virus propagates itself and spreads through the body. Importantly, determining the molecule's structure helps answer longstanding questions about how the protein breaks itself apart to advance the replication process. The discovery reveals a new vulnerability in the virus that could be targeted with drugs. |
Hunger really can make us feel 'hangry' Posted: 06 Jul 2022 12:30 PM PDT New research has discovered that feeling hungry really can make us 'hangry', with emotions such as anger and irritability strongly linked with hunger. |
Revealing one of the driving forces of Alzheimer's Posted: 06 Jul 2022 12:30 PM PDT A new study has shown how a protein called tau, a critical factor in the development of Alzheimer's disease, turns from normal to a disease state -- and demonstrates how the discovery could deliver a potential therapeutic target. Researchers hope to prevent the process from happening, thereby keeping tau in a healthy state and avoiding the toxic effects on brain cells that then result in impaired memory function. |
Honeycomb maze reveals role of hippocampus in navigation decisions Posted: 06 Jul 2022 10:33 AM PDT Researchers have discovered that the hippocampus creates a vector-based representation to support animals to make optimal navigation decisions. The researchers report results which go a long way to solving the problem of how hippocampal place cells contribute to flexible navigation. |
Multi-layered strategies needed to protect public health from oil and gas drilling impacts Posted: 06 Jul 2022 10:33 AM PDT A group of public health experts from several universities and organizations is urging adoption of a multi-layered approach when developing policies to mitigate the impact of gas and oil production operations. They lay out a framework for decision-making, which they say would facilitate the application of more public health protective measures. |
'Supergene' wreaks havoc in a genome Posted: 06 Jul 2022 10:33 AM PDT Biologists have used population genomics to shed light on the evolution and consequences of a selfish genetic element known as Segregation Distorter (SD). The researchers report that SD has caused dramatic changes in chromosome organization and genetic diversity. |
New method for studying functionality of microbiota Posted: 06 Jul 2022 10:33 AM PDT A research group has developed a new method for studying the functionality of microbiota through metaproteomics. The new method poses broad potential for the study of microbiota on a new, functional level. The characterization of the functionality of gut microbiota is central in the study of human health and disease as well as disease prediction, prevention, and treatment. Previous studies have mainly focused on cataloguing the composition of microbiota, but little is known about the functionality of the human gut microbiota. |
Climate warming could deepen environmental injustice in urban areas Posted: 06 Jul 2022 10:33 AM PDT Extreme heat events could become more intense and frequent both locally and globally, increasing the risk of harm to health and global economies, according to a new study. |
Psoriasis: Study lays foundation for new treatment strategy Posted: 06 Jul 2022 10:33 AM PDT About one third of those who suffer from psoriasis develop inflammation in their joints (psoriatic arthritis) as a result of the chronic skin condition. A research team has now discovered a key starting point for inhibiting inflammation in both psoriasis and psoriatic arthritis. The researchers' findings may form the basis for developing new treatment, diagnostic and prevention strategies. |
New imaging technique allows researchers to see gene expression in brains of live mice in real time Posted: 06 Jul 2022 05:53 AM PDT Scientists have developed a new technique for imaging mRNA molecules in the brains of living mice. The research reveals new insights into how memories are formed and stored in the brain and could allow scientists to learn more about diseases such as Alzheimer's in the future. |
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