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Patients with lupus benefit from COVID-19 vaccine booster Posted: 13 Jul 2022 12:29 PM PDT People with systemic lupus erythematosus, or SLE, who received a 'booster' dose of SARS-CoV-2 vaccine after full vaccination are roughly half as likely to have a subsequent 'breakthrough' COVID-19 infection, a new study shows. |
How mitochondrial damage ignites the 'auto-inflammatory fire' Posted: 13 Jul 2022 11:39 AM PDT Researchers describe the biochemical pathway that results in the generation of oxidized mitochondrial DNA, how it is expelled by mitochondria and how it triggers the complex and destructive inflammatory response that follows. |
Activity patterns saw dramatic shifts during and beyond COVID-19 pandemic in United Kingdom Posted: 13 Jul 2022 11:39 AM PDT A new analysis describes how U.K. residents shifted the amount of time they spent on various activities over the course of the pandemic and whether they participated online or in-person. |
Microparticles could be used to deliver 'self-boosting' vaccines Posted: 13 Jul 2022 11:39 AM PDT Engineers have developed microparticles made of a biocompatible polymer that can deliver a payload at different time points and could be used to create 'self-boosting' vaccines. |
Research reveals how brain inflammation may link Alzheimer's risk, sleep disturbance Posted: 13 Jul 2022 11:39 AM PDT Scientists have discovered that brain inflammation may link Alzheimer's disease risk with sleep disturbance, which may aid early detection and prevention efforts by identifying novel treatment targets at preclinical stages. |
How RNA processing goes awry in rare immune disease Posted: 13 Jul 2022 09:45 AM PDT Researchers have discovered a new underlying cause of Wiskott-Aldrich syndrome, a rare genetic disease that leads to bleeding and immune deficiencies in babies. Their findings revolve around how cells cut and paste strands of RNA in a process called RNA splicing. The genetic mutations associated with Wiskott-Aldrich syndrome, they found, disrupt this process which, in turn, prevents numerous immune and anti-inflammatory proteins from being made correctly. |
Uncharted genetic territory offers insight into human-specific proteins Posted: 13 Jul 2022 08:47 AM PDT An international research consortium brings together 7,200 segments of the human genome that are virtually unexplored and presents a roadmap for integrating them into human genome databases. Much of this uncharted territory is thought to code for proteins, and could hold information about what sets humans apart from other animals. The new study paves the way for brand-new research avenues into human health and disease. |
Long COVID has a significant impact on UK workforce, study finds Posted: 13 Jul 2022 08:46 AM PDT Experts looking at the effects of Long COVID on the UK workforce warn it has had a significant and potentially lasting impact on labor supply. |
Tiny gene fragments revealed as crucial new players in retinal development and vision Posted: 13 Jul 2022 08:46 AM PDT Researchers have identified a gene that is crucial for the proper development of photoreceptor cells in the retina. The gene works by regulating microexons, tiny fragments of DNA that play an important role in cell function, many of which are found in genes crucial for the cell's ability to transform light into sight. Experimentally knocking the gene out in zebrafish resulted in severely altered photoreceptors with features that closely resemble retinitis pigmentosa in humans. The findings pave the way for new lines of research that uncover the gene's role in unexplained causes of heritable retinal diseases, potentially leading to new therapeutic strategies. |
Posted: 13 Jul 2022 08:46 AM PDT Individuals with no dementia risk factors, such as smoking, diabetes or hearing loss, have similar brain health as people who are 10 to 20 years younger than them, according to a new study. The study found that a single dementia risk factor could reduce cognition by the equivalent of up to three years of aging. |
Researchers develop new agent to help root out hypertension-causing tumor Posted: 13 Jul 2022 08:46 AM PDT Researchers have developed a noninvasive method to identify a potential cause of hypertension with a drastic reduction in radiation exposure, a new study shows. The fluorine-based reagent detects whether the hormone aldosterone is being produced abnormally, which is a possible sign of an adrenal adenoma, a tumor that can cause hypertension and can be removed surgically. |
Turning white blood cells into medicinal microrobots with light Posted: 13 Jul 2022 08:46 AM PDT Medicinal microrobots could help physicians better treat and prevent diseases. But most of these devices are made with synthetic materials that trigger immune responses in vivo. Now, for the first time, researchers have used lasers to precisely control neutrophils -- a type of white blood cell -- as a natural, biocompatible microrobot in living fish. The 'neutrobots' performed multiple tasks, showing they could someday deliver drugs to precise locations in the body. |
Speeding up the search for the next COVID-19 antiviral Posted: 13 Jul 2022 08:46 AM PDT To develop new COVID-19 medications, researchers are working to target one protein, nsp13, that coronaviruses need to replicate. In a new study, one team describes a new approach to identifying molecules that interfere with this protein -- a step toward development of pan-coronavirus antivirals. |
Posted: 13 Jul 2022 08:46 AM PDT Researchers have been able to produce antibodies to the SARS-CoV-2 spike protein in hen eggs. Antibodies harvested from eggs might be used to treat COVID-19 or as a preventative measure for people exposed to the disease. |
Study confirms lead-in-water causes adverse fetal health outcomes Posted: 13 Jul 2022 08:46 AM PDT Health economics researchers have confirmed a causal relationship between lead-in-water and adverse fetal health outcomes. Although many studies have found a correlation between lead exposure and health, a causal link had been lacking in the literature -- until now. |
Curbing Candida: The cells that keep fungal infections at bay Posted: 13 Jul 2022 08:46 AM PDT Researchers have uncovered a previously unknown defense mechanism employed by the immune system in fighting Candida infections. |
Urban environments with more vegetation are associated with better health behaviors in children Posted: 13 Jul 2022 08:46 AM PDT Urban areas with more vegetation, higher density of buildings and facilities, lower population density and without major roads are associated with better health behaviors in children, according to new research. |
Incidental pulmonary embolism on chest CT: AI vs. clinical reports Posted: 13 Jul 2022 08:46 AM PDT An AI tool for detection of incidental pulmonary embolus (iPE) on conventional contrast-enhanced chest CT examinations had high NPV and moderate PPV, even finding some iPEs missed by radiologists. |
The promising drug duo that may improve spinal muscular atrophy (SMA) treatment Posted: 13 Jul 2022 08:46 AM PDT In 2016, Spinraza became the first FDA-approved treatment for spinal muscular atrophy. Researchers have found a way the therapeutic effects of Spinraza may be improved. They discovered that pairing Spinraza with a second FDA-approved drug called valproic acid may help optimize Spinraza's efficiency. |
Regular screening of people at high risk for pancreatic cancer pays off Posted: 13 Jul 2022 08:46 AM PDT Surveillance programs for people at high risk of developing pancreatic cancers can help detect precancerous conditions and cancers early, when they are most treatable, according to a new multicenter study. |
Social development of infants unaffected by COVID-19 pandemic Posted: 13 Jul 2022 08:46 AM PDT Health issues and loss, social isolation and mental health problems -- the pandemic has had a drastic effect on our society. But how have the youngest members of society been coping with these changes? Researchers have found that the presence of parents and caregivers is enough to mitigate the pandemic's negative effects on the social development of infants. |
New stem cell mechanism in your gut Posted: 13 Jul 2022 08:45 AM PDT Stem cells are a hot topic for creating medical treatments. However, scientists still do not fully understand how they choose to divide or differentiate to renew organs. Researchers have now found a new biophysical mechanism that regulates stem cells in the intestines of mice. There, a stem cell is not purely defined by intrinsic molecular markers but also by their location and movements in their environment. This could have implications for possible new treatments. |
New study reveals where memory fragments are stored Posted: 13 Jul 2022 08:45 AM PDT While the overall experience is stored in the hippocampus, the brain structure long considered the seat of memory, individual details are parsed and stored elsewhere, in the prefrontal cortex. This separation ensures that, in the future, exposure to any individual cue is sufficient to activate the prefrontal cortex, which then accesses the hippocampus for recall of the whole memory. |
Maternal milk tied to better school-age outcomes for children born preterm Posted: 13 Jul 2022 08:45 AM PDT In a study that followed preterm infants for seven years, investigators found that children who received greater quantities of maternal milk both during and after time in the neonatal intensive care unit (NICU) had greater academic achievement, higher IQs and reduced ADHD symptoms. |
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