Scientists genetically engineer mother hens to kill their own male chicks before they hatch

Scientists genetically engineer mother hens to kill their own male chicks before they hatch

A concept patent has been filed for a method that includes the use of CRISPR/Cas-mediated gene editing to generate transgenic birds so that no male offspring are able to hatch. Israeli scientists led by Dr Yuval Cinnamon (named as an inventor on the patent) are proposing this method to be used in chickens, so that only female chicks will hatch, which will then go on to become laying hens for egg production.
Currently male chicks are killed when young as they are of no use to the egg or chicken meat industries. Even then, hatching the male chicks and keeping them alive until they are killed is viewed by the industry as a waste of energy and other resources.
More seriously, the practice of killing the male chicks is an animal welfare issue. In this light, the transgenic CRISPR-edited chickens are being hyped as a boon for animal welfare, on the grounds (in the BBC’s words) that the technology could “prevent the slaughter of millions of male chickens in the UK, which are culled because they don't lay eggs”.
But our investigation shows that such claims are disingenuous in the extreme. In fact, the technology forces mother hens to pass on a lethality (killer) gene, which is intended to kill all male embryos before they hatch from the egg.
The genes that are most reliably lethal, and therefore most likely to be used, produce highly toxic proteins. The hen should only produce the toxic protein under the influence of blue light, according to the patent. However, if the technology doesn’t work perfectly, the founder breeder hens and their egg-laying daughters could produce a toxin at low levels in their bodies, leading to health problems in these chickens. The male chick embryos killed successfully with the lethality gene could, depending on the particular gene used, effectively be toxic waste and could not be put into the animal feed supply – the current destination for unwanted male chickens. And the lethality gene could escape into the environment or into bacteria, and again, depending on the gene used, could endanger humans, animals, and wildlife.
Moreover, there appears to be no proof that the technology will work as intended, as there is no evidence in the public domain that a live transgenic breeder hen has actually been produced. The experiments described in the patent are all done on cells in test tubes/flasks (in vitro) or on the egg (in ovo).
In spite of all this, the European Commission has rushed to assure the developers that the egg-laying hens and their eggs are not GMOs and can therefore be sold without safety checks and GMO labelling.
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Read on and access linked sources:
https://www.gmwatch.org/en/106-news/latest-news/20034

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