Saturday, April 10, 2021 : Issue #1122

TOP STORIES - Diabetes News & Research

Appetite-Regulating Hormones Lower After Sucrose Versus Glucose

High-Intensity Interval Training and Type 1 Diabetes: Effect on Glycemic Control

Oral Health and Diabetes Complications

Letter from the Editor

A couple of weeks ago our exercise guru, Dr. Sheri Colberg, had a great article on how different types of exercise can either raise or lower or rapidly lower your glucose levels and what your patients could do about it.

This week our intern, Aleksandra Kusic, PharmD Candidate, Florida A&M University, College of Pharmacy, takes a deeper dive by looking at how HIIT exercise can have a long term positive effect on A1c. Reading her article may give you the knowledge to keep your patients strong, healthy, and prevent hypoglycemia.

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We can make a difference!

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Dave Joffe

Editor-in-chief

Did You Know? Functional Decline Tied to Prediabetes:

Individuals with diabetes mellitus are more likely to suffer from functional decline and disability than the general population. Still, studies have not previously looked at the association between prediabetes and these outcomes over time. This study used 12 years of data from the Swedish National Study on Aging and Care to assess the impact of both diabetes and prediabetes on physical function and disability progression, and further tests whether the presence of cardiovascular disease (CVD) mediates these impacts.

The researchers found that prediabetes is associated with physical functional decline regardless of whether a patient progresses to diabetes, with concurrent CVD particularly leading to accelerated disability progression. A cohort of 2,013 participants aged ≥60 from the Swedish National Study on Aging and Care participated in the study. At baseline, 650 (32.3%) had prediabetes, and 151 had diabetes (7.5%). In multi-adjusted mixed-effect models, prediabetes was associated with an increased chair stand time (β 0.33, 95% CI 0.05-0.61), a decreased walking speed (β -0.006, 95% CI -0.010 to -0.002), and an accelerated disability progression (β 0.05, 95% CI 0.01-0.08), even after controlling for the future development of diabetes. Diabetes led to faster functional decline than prediabetes. In mediation analyses, CVDs mediated 7.1%, 7.8%, and 20.9% of the associations between prediabetes and chair stand, walking speed, and disability progression, respectively.

From the results, it was concluded that prediabetes and diabetes are associated with faster functional decline and disability, independent of the future development of diabetes. This study highlights the importance of monitoring for practical reduction among patients with prediabetes, as well as controlling both hyperglycemia and CVD as a means to reduce progression to physical disability.

Diabetes Care 2021 Mar; 44(3): 690-698.

Diabetes in Control gratefully acknowledges the assistance of the following pharmacy doctoral candidates in the preparation of this week’s newsletters:

Macrina Ghali, PharmD Candidate 2021, Florida A&M University, College of Pharmacy and Pharmaceutical Sciences

Sameen Khan, Pharm.D. Candidate, USF College of Pharmacy

Aleksandra Kusic, PharmD Candidate, Florida A&M University, College of Pharmacy and Pharmaceutical Sciences

Arjay Mendoza, PharmD Candidate, University of Colorado Denver Skaggs School of Pharmacy and Pharmaceutical Sciences

Marianis Barreto Quintana, PharmD. Candidate, LECOM School of Pharmacy

Jacob Roberts, PharmD Candidate 2021 of University of Colorado Denver Skaggs School of Pharmacy and Pharmaceutical Sciences

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Your Friends in Diabetes Care
Steve and Dave
Diabetes In Control
www.diabetesincontrol.com

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Saturday, April 10, 2021 : Issue #1122

TOP STORIES - Diabetes News & Research

TOP STORIES - Diabetes News and Research

Did You Know? Functional Decline Tied to Prediabetes:

Diabetes in Control gratefully acknowledges the assistance of the following pharmacy doctoral candidates in the preparation of this week’s newsletters: