āPeople diagnosed with early-onset bowel cancer have a 50% chance that their cancer will recur or spread to other organs following initial intervention, compared to around 30% in people diagnosed with late-onset bowel cancer.
We have evidence that ROCK activity in bowel cancers drives this process by influencing how cancers communicate with their environment. Our project will investigate how this happens.
In a practical sense, this could help us use targeted therapies that block cancer cells from communicating with their environment, in people who are most likely to experience recurrence of their cancer. It could also help us minimise the use of debilitating chemotherapies.ā ~ Professor Michael Samuel. |
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